Author  
Place of duty  
Title   항암제 내성 L1210 변이주에서 TGFβ1 의 세포생존 억제효과 ( TGFβ1 Effect on Survival of Anticancer Drug - resistant L1210 Sublines )
Publicationinfo   1998 Jan; 030(05): 1005-1014.
Key_word   TGF￥a1, Anticancer drug resistance, Growth inhibition
Full-Text  
Abstract   Purpose: The inhibitory effect of TGF￥a1 on survivals of L1210 and anticancer drug- resistant L1210 sublines was investigated and the gene expression of TGF￥a1 in these cells was examined. Materials and Methods: The survivals of L1210, adriamycin-resistant(L1210AdR), vincristine-resistant(L1210VcR) or cisplatin-resistant(L1210Cis) cells were measured by MTT assay after treatment of TGF￥a1. Northern analysis was performed for TGF￥a1 gene expression in L1210, L1210AdR, L1210VcR or L1210Cis. Results: There was no different survival ratio between two groups, control and TGF￥a1(10 ng/ml) treated groups in L1210 cells. However, the survival ratio of L1210AdR was 59% in TGF￥a1 treated group for 96 hours. The survival ratio of L1210VcR was 61% for 96 hours in TGF￥a1 treated group. The survival ratio of L1210Cis was 40% for 96 hours in TGF￥a1 treated group. Expressions of TGF￥a1 gene in drug-resistant sublines were significantly decreased than that of L1210 cells. Conclusion: Growth of anticancer drug-resistant L1210 sublines were inhibited by TGF￥a1 but not in L1210 cells. So, it is suggested that TGF￥a1 gene expression may have a part in anticancer drug-resistance.
저 자   김성용(Sung Yong Kim),이경섭(Kyung Sub Lee),김재룡(Jae Ryong Kim),김정희(Jeong Hee Kim)